The Pharmacology of Functional, Biochemical, and Recombinant Receptor Systems

Cover
Terrence P. Kenakin, James A. Angus
Springer Science & Business Media, 2000 - 448 Seiten
This, the 148th volume of the Handbook of Experimental Pharmacology series, focuses on the very core of pharmacology, namely receptor theory. It is fitting that the originator of receptor pharmacology, A.J. CLARK, authored the fourth volume of this series 63 years ago. In that volume CLARK further developed his version of receptor theory first described four years earlier in his classic book The Mode of Action of Drugs. An examination of the topics covered in volume 4 reveals a striking similarity to the topics covered in this present volume; pharmacologists today are still as interested in unlocking the secrets of dose-response relationships to reveal the biological and cheƯ mical basis of drug action as they were over half a century ago. Sections in that 1937 volume such as "Curves relating exposure to drugs with biological effects" and "Implications of monomolecular theory" show Clark's keen insight into the essential questions that required answers to move pharmaƯ cology forward. With the advent of molecular biological cloning of human receptors has come a transformation of receptor pharmacology. Thus the expression of human receptors into surrogate host cells helped unlock secrets of receptor mechanisms and stimulus-transduction pathways. To a large extent, this elimƯ inates the leap of faith required to apply receptor activity of drugs tested on animal receptor systems to the human therapeutic arena. However, a new leap of faith concerning the veracity of the effects found in recombinant systems with respect to natural ones is now required.
 

Was andere dazu sagen - Rezension schreiben

Es wurden keine Rezensionen gefunden.

Inhalt

II
15
III
16
IV
21
V
27
VI
28
VII
29
VIII
31
IX
33
CIV
227
CV
231
CVI
233
CVII
235
CVIII
238
CIX
241
CX
244
CXII
248

X
34
XI
37
XII
38
XIII
41
XV
47
XVI
51
XVII
52
XIX
55
XX
56
XXI
59
XXII
61
XXIII
62
XXIV
64
XXV
66
XXVI
68
XXVII
70
XXVIII
71
XXIX
72
XXX
76
XXXI
80
XXXII
81
XXXIV
82
XXXVI
84
XXXVII
87
XXXVIII
88
XXXIX
90
XLI
91
XLII
95
XLIII
101
XLV
105
XLVII
107
XLVIII
119
XLIX
120
L
121
LI
122
LII
123
LIII
124
LIV
126
LVI
131
LVII
134
LVIII
139
LIX
143
LX
144
LXI
147
LXII
148
LXIII
149
LXIV
151
LXV
152
LXVI
155
LXVII
158
LXVIII
163
LXX
167
LXXI
168
LXXII
173
LXXIII
174
LXXIV
177
LXXV
178
LXXVII
183
LXXVIII
186
LXXIX
188
LXXXI
191
LXXXII
192
LXXXIII
195
LXXXIV
196
LXXXV
197
LXXXVI
201
LXXXVII
204
LXXXVIII
206
LXXXIX
208
XC
210
XCI
212
XCII
214
XCIII
215
XCV
217
XCVI
218
XCVII
219
XCIX
220
C
221
CI
222
CII
223
CIII
225
CXIII
254
CXIV
261
CXVIII
267
CXX
268
CXXI
271
CXXII
273
CXXIII
274
CXXIV
276
CXXV
278
CXXVI
279
CXXVII
280
CXXVIII
283
CXXIX
287
CXXXI
288
CXXXII
289
CXXXIII
291
CXXXV
293
CXXXVI
294
CXXXVII
296
CXXXIX
298
CXL
299
CXLI
300
CXLII
302
CXLIII
304
CXLIV
313
CXLV
314
CXLVII
316
CXLVIII
318
CXLIX
323
CL
328
CLII
335
CLV
336
CLVI
338
CLVIII
342
CLIX
343
CLX
345
CLXI
346
CLXII
348
CLXIII
349
CLXIV
350
CLXVI
354
CLXVII
355
CLXVIII
356
CLXX
363
CLXXI
364
CLXXII
365
CLXXIII
367
CLXXIV
370
CLXXV
380
CLXXVI
383
CLXXVIII
391
CLXXIX
392
CLXXX
393
CLXXXII
397
CLXXXIII
400
CLXXXV
401
CLXXXVI
402
CLXXXVII
405
CLXXXIX
409
CXC
411
CXCII
412
CXCIII
415
CXCV
417
CXCVII
419
CXCVIII
421
CC
422
CCIII
423
CCVII
424
CCIX
425
CCXII
426
CCXIII
427
CCXV
428
CCXVII
429
CCXVIII
431
CCXIX
432
CCXX
433
CCXXI
434
CCXXII
435
CCXXIV
441
Urheberrecht

Andere Ausgaben - Alle anzeigen

Häufige Begriffe und Wortgruppen

Bibliografische Informationen