Genes, Environment, and Psychopathology: Understanding the Causes of Psychiatric and Substance Use Disorders

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Guilford Press, 01.11.2007 - 412 Seiten
This groundbreaking volume synthesizes the results of the Virginia Adult Twin Study of Psychiatric and Substance Use Disorders, which yielded longitudinal data on more than 9,000 individuals. The authors trace how risk for depression, anxiety, eating disorders, antisocial behavior, alcoholism, and substance abuse emerges from the interplay of a variety of genetic and environmental influences. Major questions addressed include whether risk is disorder-specific, how to distinguish between correlational and causal genetic and evironmental factors, sex differences in risk, and how risk and protective factors interact over time. The book also summarizes the conceptual underpinnings of the study and describes key methodological challenges and innovations.
 

Inhalt

Introduction
1
PART IBACKGROUND
9
CHAPTER ONEThe Scientific and Social Context of the Virginia Adult Twin Study of Psychiatric and Substance Use Disorders
11
CHAPTER TWOMethodology Used in the VATSPSUD
20
CHAPTER THREETwinning and Twin Models
34
PART IIGENETIC RISK
49
CHAPTER FOURInternalizing Disorders
51
CHAPTER FIVEExternalizing and Substance Use Disorders
81
CHAPTER ELEVENThe Genetics of What?
199
CHAPTER TWELVEThree Extensions of the Twin Model
229
PART VBRINGING IT ALL TOGETHER
249
CHAPTER THIRTEENThe Genetics of the Environment
251
CHAPTER FOURTEENMechanisms for Genetic Control of Exposure to the Environment
267
CHAPTER FIFTEENIs the Relation between Environmental Risk Factors and Psychiatric Disorders Causal?
275
CHAPTER SIXTEENGenetic Control of Sensitivity to the Environment
291
CHAPTER SEVENTEENIntegrative Models
320

CHAPTER SIXTwin Model Assumptions
114
PART IIIENVIRONMENTAL RISK
127
CHAPTER SEVENChildhood Experiences and Risk for Psychopathology
129
CHAPTER EIGHTAdult Experiences and Risk for Psychopathology
148
PART IVA CLOSER LOOK AT GENETIC AND ENVIRONMENTAL INFLUENCES
167
CHAPTER NINESex Differences
169
CHAPTER TENGenetic and Environmental Influences on Stability and Change
181
CHAPTER EIGHTEENConclusions
339
References
351
Publications from the VATSPSUD
377
Author Index
391
Subject Index
401
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Autoren-Profil (2007)

Kenneth S. Kendler, MD, is the Banks Distinguished Professor of Psychiatry and Professor of Human Genetics at the Medical College of Virginia, Virginia Commonwealth University. Since 1983, he has been engaged in studies of the genetics of psychiatric and substance use disorders, and he has been the director of the Virginia Adult Twin Study of Psychiatric and Substance Use Disorders since its inception. Dr. Kendler's work has utilized the methods of both large-scale population-based twin studies and molecular genetics. He has published over 430 peer-reviewed articles, has received a number of national and international awards, is a member of the Institute of Medicine of the National Academy of Sciences, serves on several editorial boards, and is Editor of Psychological Medicine. Since 1996, Dr. Kendler has served as Director of the Virginia Institute for Psychiatric and Behavioral Genetics.

Carol A. Prescott, PhD, is Professor of Psychology at the University of Southern California. From 1992 to 2005, she was on the faculty of the Virginia Institute for Psychiatric and Behavioral Genetics of Virginia Commonwealth University, where she served as Co-Director of the Virginia Adult Twin Study of Psychiatric and Substance Use Disorders. Dr. Prescott has published extensively on genetic influences on alcoholism and other forms of psychopathology. She serves as Associate Editor for Behavior Genetics and Alcoholism: Clinical and Experimental Research. Her honors include election to membership in the Society for Multivariate Experimental Psychology and the Theodore Reich Prize from the International Society on Psychiatric Genetics.

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