Molecular Biology of Circadian RhythmsAmita Sehgal John Wiley & Sons, 2004 - 283 Seiten This text begins with a general introduction to biochemical and biophysical aspects of circadian timing, then proceeds to its essential focus on collating the newest information on molecular mechanisms of circadian rhythms. It includes a chapter on the implications for clinical research on affective disorders, sleep disorders, and the relevance for therapeutic treatment, as well as coverage of multiple oscillators and hormonal rhythms. Sections include: Molecular Control of Circadian Rhythms: Animal Models Molecular Control of Circadian Rhythms: From Cyanobacteria to Plants Circadian Organization in Complex Organisms. Chapter topics include examinations of circadian rhythms in non-mammalian vertebrates, neurospora, and humans. |
Inhalt
General Concepts | 3 |
Genetic and Molecular Approaches Used | 17 |
PART II | 31 |
Nonmammalian | 75 |
Genetic Basis for Circadian Rhythms in Mammals | 93 |
Circadian Rhythms in Cyanobacteria | 143 |
Molecular Analysis of Circadian Rhythms in Neurospora | 171 |
Physiological and Molecular Characteristics of Plant | 185 |
Multiple Oscillators | 213 |
Hormonal Rhythms | 231 |
Human Circadian Rhythms | 255 |
| 271 | |
Häufige Begriffe und Wortgruppen
acid animals Arabidopsis arrhythmic assay behavior bHLH binding biology BMAL1 brain cadian casein kinase CCA1 cells circa circadian clock circadian gene circadian oscillator circadian period circadian rhythms circadian system clock genes clock protein clock-controlled cloned components constant darkness CREB cryptochromes cyanobacteria cyclic dClk dian domain Drosophila eclosion effects encodes endogenous entrainment flies freerunning gene expression genetic genome homologs hormone humans hypothalamus interaction KaiA KaiC kinase knockout lateral neurons levels light pulse light-dark cycle locomotor activity luciferase mammalian mammals mechanism mediate melatonin mice molecular mPer2 mPerl mRNA mutant neurons Neurospora night nuclear organisms output pathways overexpression peak Per2 peripheral oscillators phase phenotype phosphorylation photoreceptor physiological phytochrome pituitary plants promoter receptor release reset response to light retina rhythmic expression role SasA secretion sequence signal sleep specific temperature tion tissues tran transcription factors transgenic vitro wild type wild-type zebrafish zeitgeber