Essentials of Genomics and BioinformaticsChristoph W. Sensen John Wiley & Sons, 07.05.2002 - 419 Seiten Provides an overview of the rapidly evolving field of genomics with coverage of nucleic acid technologies, proteomics and bioinformatics. It includes chapters on applications in human health, agriculture and comparative genomics and also contains two chapters on the legal and ethical issues of genomics, a topic that is becoming increasingly important as genomics moves out of the laboratory into practical applications. |
Inhalt
Dr Lyle R Middendorf Prof Dr Renate RenkawitzPohl | 7 |
Dr David Wishart Dr Zheru Zhang | 10 |
Genomic Data Representation through Ethical Legal and Social Issues | 15 |
Germany | 16 |
Genome Projects of Selected Eukaryotic Model Organisms | 20 |
Dr Chandra S Ramanathan Dr Kevin Rozwadowski | 21 |
Chapter 5 | 35 |
Dr Doris Jording Dr Rodrigo Lopez | 52 |
Introduction | 330 |
Protein Fold | 331 |
Evolution and ThreeDimensional Structure | 333 |
Structure to Function Structural Signatures | 334 |
Homology Modeling | 335 |
Fold Recognition by Threading | 336 |
Virtual Screening | 337 |
Molecular Machines | 338 |
Pharmaceutical Bioinformatics and Drug phoresis 253 | 105 |
AgriFood and Genomics | 127 |
References | 198 |
Chapter 1 | 210 |
| 265 | |
Introduction | 267 |
Dr Rolf Apweiler Dr Detlev Buttgereit | 268 |
The SRS Approach | 276 |
Genomic Mapping and Positional Cloning T Etzold | 285 |
Dr Thure Etzold Dr Christopher Hogue | 307 |
T Toojinda 13 Tools for Protein Technologies | 309 |
| 329 | |
De novo Protein Design | 339 |
References | 341 |
Dr HansPeter Klenk Dr Alan Matte | 345 |
Bader Dr Miroslaw Cygler | 366 |
BARTHA MARIA KNOPPERS | 384 |
Prof Bartha Maria Knoppers Dr David Michels | 390 |
Ownership | 391 |
Bader C W V Hogue B M Knoppers | 398 |
Genomic Data and Data Handling | 401 |
| 407 | |
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2D gel Acad alignment alleles amino acid Anal analysis annotation Arabidopsis automated base bioinformatics Biol biological capillary capillary electrophoresis cDNA cell chromosome cloning codon coli colon cancer complete contigs cystic fibrosis databanks detection disorder DNA sequencing domain Drosophila dyes elegans enzymes example fluorescence fragments fulgidus function gaps gel electrophoresis genetic disease Genome Project genome sequencing human genome Human Genome Project identified interaction JORDE labeled linkage linked markers mass spectrometry matches ment methods microarrays molecular molecules MS/MS mutations Natl nome Nucleic Acids Nucleic Acids Res nucleotide oligonucleotide ORFs organisms peptide peptide mass fingerprinting Pfam phenotype physical map plant polymorphisms population positional cloning prediction primer Proc profiles programs protein sequence proteome quence regions sample Science sequence databases SNPs specific strategy structure SWISS-PROT syndrome target techniques tein tion traits yeast